The FXYD5 Antibody (Center) from MyBioSource.com is a Rabbit Polyclonal antibody to Dysadherin, FXYD5, IWU1, and Ric. This antibody recognizes Human antigen. The FXYD5 Antibody (Center) has been validated for the following applications: ELISA, Immunohistochemistry, and Western Blot.
Description
This gene encodes a member of a family of small membrane
proteins that share a 35-amino acid signature sequence domain,
beginning with the sequence PFXYD and containing 7 invariant and 6
highly conserved amino acids. The approved human gene nomenclature
for the family is FXYD-domain containing ion transport regulator.
Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2,
also known as the gamma subunit of the Na,K-ATPase, regulates the
properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma),
FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to
induce channel activity in experimental expression systems.
Transmembrane topology has been established for two family members
(FXYD1 and FXYD2), with the N-terminus extracellular and the
C-terminus on the cytoplasmic side of the membrane. This gene
product, FXYD5, is a glycoprotein that functions in the
up-regulation of chemokine production, and it is involved in the
reduction of cell adhesion via its ability to down-regulate
E-cadherin. It also promotes metastasis, and has been linked to a
variety of cancers. Alternative splicing results in multiple
transcript variants. [RefSeq curation by Kathleen J. Sweadner,
Ph.D., sweadner@helix.mgh.harvard.edu.]